Can I simulate the lumen formation in tissues?


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1
7 days ago by
Yuan  
Hi everyone, I try to simulate the formation and fusion of lumens in the tissue. The sketch is as follows. The black hole is the lumen. Each lumen is between two cells.


I wonder if you could give me some advice, how can I simulate the initial lumen in CC3D? In my scenario, the lumen may exert a pressure on the surrounding cells so that it can extend. Besides the cells need to contract by themselves. Thank you!

Community: CompuCell3D

3 Answers


3
6 days ago by
Yes, the best way to model a lumen is probably as "cells". Basically, blobs of water (or blood, or ...)
3
3 days ago by
See this paper for details https://www.ncbi.nlm.nih.gov/pubmed/27193300
The paper is very detailed and a good source- thank you for the suggestion! We need a Journal Club on the forum!
written 2 days ago by Scott H  
0
7 days ago by
I am curious about this as well. What type of tissue is this? If in 2D, you could initialize a cell type for the lumen "space"
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