How to control the shape of a cluster of cells?

9 months ago by
Hi, everyone. In my simulation, there is a cluster of cells undergoing cell division. I wonder if I can get the  perimeter L of them and add an energy term,  $\frac{1}{2}k\left(L-L_0\right)^2$12 k(LL0)2 .
I want to simulate the intercellular actin cable et al. in this way.

1 Answer

9 months ago by
That looks like the surface area plugin with   $\lambda_{surface}=\frac{k}{2}$λsurƒ ace=k2 . (In 2d, it generalizes to a perimeter. Should help control `pixel' distribution at the periphery)
Can the plugin be used for a cluster of cells (i.e. control the total surface area of these cells not for each cell)?
written 9 months ago by Yuan 
I might have misunderstood your original question. By `perimeter' you are referring to the resulting shape at the boundary the cluster is forming (are your cells in a ring?) I don't believe you should directly try adding a term that signifies the target length arising from a group of single cells. Best case scenario would probably be using focal point plasticity links(similar to your equation form) between neighboring cell pairs in the cluster in order to control L0,like breaking up L0 into smaller pieces.    
written 9 months ago by priyomadhyapok 
Actually, the shape is a disc or other polygons, not only a ring. I want to apply the constraint, $\frac{1}{2}k\left(L-L_0\right)^2$12 k(LL0)2 , on the outermost ring of cells. The biological background is, the outermost cells contract to exert a force on the inners. Both the outer and inner cells are of the same type and they are under mitosis. Is it possible to simulate this in CC3D?
Besides, what's the meaning of volume and surface in 2D simulation? I do not see the description in the CC3D tutorial. For example, a cell is made up of 2*2 pixels in 2D, then the surface is 8 and the volume is 4?
Thank you.
written 9 months ago by Yuan 
So the point I was trying to make was you can only break your constraint length into smaller lengths and control it using FPP. The Hamiltonian in CC3D is a sum over individual cell components and their interactions.

In 2d, cell volume would generalize to the total number of pixels for the cell. So if you have a 'squarish' cell of 3 by 3, the total number of pixels in this case is 9 which is the volume. Cell surface is given by how the cell is in contact with the boundary, in this case 3*4=12.
written 9 months ago by priyomadhyapok 
Yeah, I will have a try. Thank you so much.
written 9 months ago by Yuan 
Hello, Yuan

My name is Jingwei Qiu, I am an artist now basic between Beijing and SFO. I am working on a project that need somebody familiar this model , but is hard to find programer who have the knowledge both in bio-cell and computing, so let me know can I ask the help from you, we can discuss the treatment。 Thank you
written 4 months ago by Jing Wei Qiu 
Hello Jingwei,
I am not sure whether I can meet your requirements. So what do you want to do specifically?
written 4 months ago by Yuan 
Thank you so much for your reply! can we add a qq or wechat? So that I can share more detail with you.
my QQ:1071787728 Thank you!
written 4 months ago by Jing Wei Qiu 
This program is barely used by people,its very professional.All my programmer friend can only understand few function in it.
written 4 months ago by Jing Wei Qiu 
Hey, Yuan

Do you normally use QQ? I would love to go further in that topic with you,Let me know how you think)
written 4 months ago by Jing Wei Qiu 
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