How to specify the values of the parameters in GGH model?
23 days ago by
1. How to specify the values of parameters in the model? For example, adhesion energy J, elastic constants K. Can I set them according to the experiments? How to realize?
2. As for the time, the Monto Carol Step(MCS) is determined by the real-time. However, the values of the parameters in simulation based on the relationship of MCS and real-time and the values have an impact on the total MCSs, i.e. they are coupled. How to solve this?
3. How to specify the relative values of the parameters?
22 days ago by
If I understand the question correctly, the way I map MCS to real time is to look at the average square displacement of cells in experiments and simulations and then use this to directly map MCS to real time.
Mapping adhesion energy to experiments is more complicated, unless you can extract real values or find values in literature, it is very difficult, one possible way is to use ratios depending on the minimization or maximization of cell boundary interfaces, i.e if two cells in a non confluent environment in contact increase their shared contact area they more adhesive than cells that decrease their contact area.
10 days ago by
Alternatively, you can scan the mcs to time relationship. Compare the results of simulations with 1 mcs= 1 hour, 1 minute, 1 second, 1 millisecond, ... Usually there will be a range of time scales where the simulation output changes with the time scale and another range of time scales where the output doesn't change. You want your simulation to be running in the time step size independent domain.
Please login to add an answer/comment or follow this question.